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apalutamide will lower the level or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which are CYP3A4 substrates may result in reduced exposure to these prescription drugs.Modafinil can be routine-forming. Under no cir